Figure 2. MIG-2 and INA-1 control the cell migratory capacity of QL.ap. (A) QL.ap migrates toward the tail in a WT animal but fails to complete its posterior migration in mig-2(rh17) or ina-1(gm144) mutant animals. The plasma membrane of QL.ap is visualized by the expression of MIG-2∷GFP (image is inverted so that higher GFP intensity is black). The leading edge of QL.ap is marked by red arrows, and the rear of the stationary QL.p is marked by purple arrowheads. Bar, 5 µm. (B) The distance between QL.ap and QL.pa during migration in WT, ina-1(gm144), and mig-2(rh17). (C) The final migration distances of QL.ap in ina-1(gm144) (13.3 ± 3.3 µm, n = 22) and mig-2(rh17) (13.0 ± 3.5 µm, n = 11) mutants are shorter than that in WT (28.9 ± 5.2 µm, n = 18). Error bars indicate SEM. (D) The migration speeds of QL.ap in ina-1(gm144) (5.6 ± 1.2 µm/h, n = 12) and mig-2(rh17) (7.8 ± 2.1 µm/h, n = 11) mutants are slower than in WT (16.8 ± 3.3 µm/h, n = 23).
Figure 2.

MIG-2 and INA-1 control the cell migratory capacity of QL.ap. (A) QL.ap migrates toward the tail in a WT animal but fails to complete its posterior migration in mig-2(rh17) or ina-1(gm144) mutant animals. The plasma membrane of QL.ap is visualized by the expression of MIG-2∷GFP (image is inverted so that higher GFP intensity is black). The leading edge of QL.ap is marked by red arrows, and the rear of the stationary QL.p is marked by purple arrowheads. Bar, 5 µm. (B) The distance between QL.ap and QL.pa during migration in WT, ina-1(gm144), and mig-2(rh17). (C) The final migration distances of QL.ap in ina-1(gm144) (13.3 ± 3.3 µm, n = 22) and mig-2(rh17) (13.0 ± 3.5 µm, n = 11) mutants are shorter than that in WT (28.9 ± 5.2 µm, n = 18). Error bars indicate SEM. (D) The migration speeds of QL.ap in ina-1(gm144) (5.6 ± 1.2 µm/h, n = 12) and mig-2(rh17) (7.8 ± 2.1 µm/h, n = 11) mutants are slower than in WT (16.8 ± 3.3 µm/h, n = 23).

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