Figure 6. Spatial distribution of positively selected variants across type III IFN genes. Genomic organization of the three members of the type III IFN family, IL28B, IL28A, and IL29. Filled boxes correspond to exonic regions, and arrows above exons indicate the direction of the open reading frame. Genetic variants displaying signatures of population-specific positive selection are shown; noncoding SNPs are indicated in black and amino acid changes in red. At the gene level, IL28A and IL28B displayed signatures of positive selection in Asia, and IL29 in both Europe and Asia (Table 2). At the SNP level, the action of positive selection targeting the five SNPs at IL28B and the two at IL28A was supported by the DIND test (Fig. 4), whereas that at the IL29 D188N variant was supported by the DIND test and iHS, as well as by the levels of population differentiation (Fig. 5).
Figure 6.

Spatial distribution of positively selected variants across type III IFN genes. Genomic organization of the three members of the type III IFN family, IL28B, IL28A, and IL29. Filled boxes correspond to exonic regions, and arrows above exons indicate the direction of the open reading frame. Genetic variants displaying signatures of population-specific positive selection are shown; noncoding SNPs are indicated in black and amino acid changes in red. At the gene level, IL28A and IL28B displayed signatures of positive selection in Asia, and IL29 in both Europe and Asia (Table 2). At the SNP level, the action of positive selection targeting the five SNPs at IL28B and the two at IL28A was supported by the DIND test (Fig. 4), whereas that at the IL29 D188N variant was supported by the DIND test and iHS, as well as by the levels of population differentiation (Fig. 5).

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