Figure 4. Detection of positive selection in Asia using the DIND test. We plotted iπA/iπD values against derived allele frequencies (DAFs). P-values were obtained by comparing the iπA/iπD values for the three type III IFN genes against the expected iπA/iπD values obtained in 104 simulations, taking into account the most conservative demographic model (Laval et al., 2010). The top dashed line on the graph corresponds to the 99th percentile, and the bottom to the 95th percentile. Dots above the 95th percentile dashed line correspond to mutations that have increased in frequency faster than expected under neutrality in the Asian population. These mutations have been most likely targeted by positive selection, and thus conferred an advantage to the host. Red and black dots correspond to nonsynonymous and silent polymorphisms, respectively. For DIND analyses concerning all genes encoding the 27 IFNs and their receptors in all populations, see Fig. S3.
Figure 4.

Detection of positive selection in Asia using the DIND test. We plotted iπA/iπD values against derived allele frequencies (DAFs). P-values were obtained by comparing the iπA/iπD values for the three type III IFN genes against the expected iπA/iπD values obtained in 104 simulations, taking into account the most conservative demographic model (Laval et al., 2010). The top dashed line on the graph corresponds to the 99th percentile, and the bottom to the 95th percentile. Dots above the 95th percentile dashed line correspond to mutations that have increased in frequency faster than expected under neutrality in the Asian population. These mutations have been most likely targeted by positive selection, and thus conferred an advantage to the host. Red and black dots correspond to nonsynonymous and silent polymorphisms, respectively. For DIND analyses concerning all genes encoding the 27 IFNs and their receptors in all populations, see Fig. S3.

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