Figure 5. A20 deficiency in IECs sensitizes mice to TNF-induced toxicity. (A and B) Mice were injected i.p. with 5 µg of recombinant mouse TNF. Body temperature (A) and survival (B) of A20IEC-KO mice (n = 8) and littermate control mice (WT; n = 6). (C) Serum IL-6 and MCP-1 levels 4 h after mouse TNF injection. (D) Body temperature of A20IEC-KO mice (n = 6) and control littermate mice (n = 6) after injection with 50 µg of recombinant human TNF. Data are representative of three independent experiments. Error bars represent SEM. *, P < 0.05.
Figure 5.

A20 deficiency in IECs sensitizes mice to TNF-induced toxicity. (A and B) Mice were injected i.p. with 5 µg of recombinant mouse TNF. Body temperature (A) and survival (B) of A20IEC-KO mice (n = 8) and littermate control mice (WT; n = 6). (C) Serum IL-6 and MCP-1 levels 4 h after mouse TNF injection. (D) Body temperature of A20IEC-KO mice (n = 6) and control littermate mice (n = 6) after injection with 50 µg of recombinant human TNF. Data are representative of three independent experiments. Error bars represent SEM. *, P < 0.05.

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