Enterocyte expression of A20 is required for recovery of mice from acute DSS-induced inflammation. (A) Clinical score of A20^IEC-KO mice (n = 18) and control littermates (WT, n = 20) treated with 1.5% DSS. (B) Colon length of A20^IEC-KO mice (n = 18) and control littermates (WT, n = 20) after 10 d of 1.5% DSS treatment. (C) Hematoxylin and eosin (H&E) histology on DSS-treated A20^IEC-KO mice and control littermates (WT). Bars: (days 2 and 4) 100 µm; (day 10) 250 µm. (D) Serum IL-6 levels after 1.5% DSS treatment for 4 d. (E and F) Clinical score and body weight of A20^IEC-KO mice (n = 6) and control littermates (WT, n = 5) treated for 6 d with 1.5% DSS followed by normal drinking water. Data in A–D are representative of three independent experiments. Experiments in E and F were performed two times. Error bars represent SEM. *, P < 0.05.