Figure 2.
Figure 2. CD47 ablation protects from the development of TNBS colitis. TNBS colitis was induced on day 0 alone or on days 0 and 7 (circled). (A) Weight loss curves of WT and CD47 KO mice injected intrarectally with saline (control), ethanol alone, or TNBS dissolved in 50% ethanol on day 0. (B–E) Macroscopic (B and D) and histological (C and E) analyses of inflammation in WT and CD47 KO mice. Data represent means ± SEM of more than eight mice per group, and one representative experiment out of three is shown. (F) Weight loss curves of WT and CD47 KO mice injected intrarectally with 2 mg TNBS dissolved in 50% ethanol on days 0 and 7. (G and H) Macroscopic (G) and histological (H) analyses of inflammation in WT and CD47 KO mice after reinduction of TNBS colitis. Data represent means ± SEM of six mice per group. One representative experiment out of three is shown. *, P < 0.05; **, P < 0.01.

CD47 ablation protects from the development of TNBS colitis. TNBS colitis was induced on day 0 alone or on days 0 and 7 (circled). (A) Weight loss curves of WT and CD47 KO mice injected intrarectally with saline (control), ethanol alone, or TNBS dissolved in 50% ethanol on day 0. (B–E) Macroscopic (B and D) and histological (C and E) analyses of inflammation in WT and CD47 KO mice. Data represent means ± SEM of more than eight mice per group, and one representative experiment out of three is shown. (F) Weight loss curves of WT and CD47 KO mice injected intrarectally with 2 mg TNBS dissolved in 50% ethanol on days 0 and 7. (G and H) Macroscopic (G) and histological (H) analyses of inflammation in WT and CD47 KO mice after reinduction of TNBS colitis. Data represent means ± SEM of six mice per group. One representative experiment out of three is shown. *, P < 0.05; **, P < 0.01.

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