Figure 1. Wnt signaling and the BBB. Depiction of the primary constituents of the tight junction (TJ) and the adherens junction (AJ) at the interface between endothelial cell plasma membranes. Activation of Wnt receptors FZD and LRP5/6 inhibits GSK3 to stabilize β-catenin that in turn enters the nucleus to activate T cell factor (TCF)–dependent transcription. This drives Cldn3 gene activation either directly or indirectly (dashed line arrow), and the resulting Cldn protein reinforces the tight junction. JAM, junctional adhesion molecule.
Figure 1.

Wnt signaling and the BBB. Depiction of the primary constituents of the tight junction (TJ) and the adherens junction (AJ) at the interface between endothelial cell plasma membranes. Activation of Wnt receptors FZD and LRP5/6 inhibits GSK3 to stabilize β-catenin that in turn enters the nucleus to activate T cell factor (TCF)–dependent transcription. This drives Cldn3 gene activation either directly or indirectly (dashed line arrow), and the resulting Cldn protein reinforces the tight junction. JAM, junctional adhesion molecule.

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