Figure 7.
Figure 7. TSLP–TSLPR interactions limit proinflammatory cytokine production and inflammation in DSS colitis. (A) Weight loss. (B) Total pathology score for WT and TSLPR−/− mice on 5% DSS. (C) Paraffin-embedded cecal sections from day 4 after DSS administration were stained with H&E. Bars, 50 µm. (D) Total number of CD4+ IFN-γ+ T cells isolated from the MLNs at day 4 after DSS. (E) Cytokine production from anti-CD3/anti-CD28–restimulated MLN cells was determined by ELISA. (F) Colon of day 6 DSS-treated WT and TSLPR−/− mice, Bars, 1 cm. (G) Colonic shortening. Data are presented as the percent length of naive. Results represent means ± SEM. Data are representative of three individual experiments with four to five mice per group. *, P ≤ 0.05; **, P ≤ 0.08.

TSLP–TSLPR interactions limit proinflammatory cytokine production and inflammation in DSS colitis. (A) Weight loss. (B) Total pathology score for WT and TSLPR−/− mice on 5% DSS. (C) Paraffin-embedded cecal sections from day 4 after DSS administration were stained with H&E. Bars, 50 µm. (D) Total number of CD4+ IFN-γ+ T cells isolated from the MLNs at day 4 after DSS. (E) Cytokine production from anti-CD3/anti-CD28–restimulated MLN cells was determined by ELISA. (F) Colon of day 6 DSS-treated WT and TSLPR−/− mice, Bars, 1 cm. (G) Colonic shortening. Data are presented as the percent length of naive. Results represent means ± SEM. Data are representative of three individual experiments with four to five mice per group. *, P ≤ 0.05; **, P ≤ 0.08.

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