Figure 7. SOD1 overexpression attenuates age-dependent oxidative stress and SCH9 overexpression–induced genomic instability. (A) Mutation frequency (Canr) of cells during normal chronological aging. (B) Mutation frequency (Canr) of cells treated with 1 mM paraquat on day 1 and on day 3. Strains shown are wild type (WT; DBY476), sch9Δ, and cell overexpression of SOD1 and/or SCH9. *, P < 0.05; mutant versus WT. ^, P < 0.01; mutant versus sch9Δ, two-tailed t test at the indicated time points (n = 5). Error bars indicate ±SEM.
Figure 7.

SOD1 overexpression attenuates age-dependent oxidative stress and SCH9 overexpression–induced genomic instability. (A) Mutation frequency (Canr) of cells during normal chronological aging. (B) Mutation frequency (Canr) of cells treated with 1 mM paraquat on day 1 and on day 3. Strains shown are wild type (WT; DBY476), sch9Δ, and cell overexpression of SOD1 and/or SCH9. *, P < 0.05; mutant versus WT. ^, P < 0.01; mutant versus sch9Δ, two-tailed t test at the indicated time points (n = 5). Error bars indicate ±SEM.

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