Figure 5. Exogenous syndecan-4 protects mice from ConA-induced hepatic injury. (A) Exogenous syndecan-4 protects mice from ConA-induced hepatic injury, as judged by plasma ALT levels and plasma IFN-γ levels at 12 h after ConA injection. Normal human IgG (Cont Ig) was used as a control IgG (n = 10 per each group). (B) Liver-infiltrating leukocytes were prepared from Syn4Ig- or control normal human IgG (Cont Ig)–treated mice at 12 h after ConA injection (n = 5 per group). The number of CD45-positive leukocytes and F4/80-positive macrophages was determined by flow cytometry. (C) Representative histology of liver sections stained by H-E at 24 h after ConA injection. The degenerative area per liver section was quantified by using ImageJ (n = 4 per each group). Data are presented as means ± SEM. *, P < 0.05; **, P < 0.005. Bar, 500 μm. (D) Schematic illustration of the in vivo role of syndecan-4 in OPN-mediated inflammatory reactions.
Figure 5.

Exogenous syndecan-4 protects mice from ConA-induced hepatic injury. (A) Exogenous syndecan-4 protects mice from ConA-induced hepatic injury, as judged by plasma ALT levels and plasma IFN-γ levels at 12 h after ConA injection. Normal human IgG (Cont Ig) was used as a control IgG (n = 10 per each group). (B) Liver-infiltrating leukocytes were prepared from Syn4Ig- or control normal human IgG (Cont Ig)–treated mice at 12 h after ConA injection (n = 5 per group). The number of CD45-positive leukocytes and F4/80-positive macrophages was determined by flow cytometry. (C) Representative histology of liver sections stained by H-E at 24 h after ConA injection. The degenerative area per liver section was quantified by using ImageJ (n = 4 per each group). Data are presented as means ± SEM. *, P < 0.05; **, P < 0.005. Bar, 500 μm. (D) Schematic illustration of the in vivo role of syndecan-4 in OPN-mediated inflammatory reactions.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal