Figure 4.
Intratumor OX40 triggering induces tumor rejection. 5 × 104 CT26 cells were injected s.c. in the right flank of BALB/c mice. When tumors reached 3–4 mm in size, they received intratumor injection of 100 μg of purified rat IgG (A), anti-OX40 (B), anti-CD25 (C), or anti-CD4 mAb (D). Tumor volume was calculated as longest diameter × (shortest diameter)2 (in cubic millimeters). Lines represent the tumor growth kinetics in each single mouse. The number of tumor-free mice out of the number of treated mice is indicated. One representative of three independent experiments is shown.
