Figure 2. Impaired inflammatory response in Rage−/− mice. (A) Innate immune cells within the stroma of at least six wt and Rage−/− tumors were counted based on indirect IF stainings for neutrophils (antineutrophils, black bars) and macrophages (anti-CD68, gray bars), or on toluidine blue staining for mast cells (white bars), and are given as cells per square millimeter. Values represent means ± SEM from three mice from each genotype. (B) Representative pictures of hematoxylin-eosin–stained wt and Rage−/− skin specimens that were collected at the indicated time points after a single topical treatment of acetone (co) or 10 nmol TPA in acetone. Dashed lines indicate the border between the epidermis and dermis. Bar, 20 μm. (C) Innate immune cells within the dermis of at least three wt and Rage−/− mice treated as described in B were counted based on specific stainings and analyzed as described in A.
Figure 2.

Impaired inflammatory response in Rage−/− mice. (A) Innate immune cells within the stroma of at least six wt and Rage−/− tumors were counted based on indirect IF stainings for neutrophils (antineutrophils, black bars) and macrophages (anti-CD68, gray bars), or on toluidine blue staining for mast cells (white bars), and are given as cells per square millimeter. Values represent means ± SEM from three mice from each genotype. (B) Representative pictures of hematoxylin-eosin–stained wt and Rage−/− skin specimens that were collected at the indicated time points after a single topical treatment of acetone (co) or 10 nmol TPA in acetone. Dashed lines indicate the border between the epidermis and dermis. Bar, 20 μm. (C) Innate immune cells within the dermis of at least three wt and Rage−/− mice treated as described in B were counted based on specific stainings and analyzed as described in A.

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