Peptidic sequence and genomic structure of Drosophila FoxK. (A) Sequence alignment of the FH domains of Drosophila FoxK, human ILF, and murine MNF. Identical and conserved amino acids are indicated in black shading. The bipartite nuclear localization sequence (NLS) is indicated in red. The three α helices (H1–3) and the two winged loops (W1 and 2) are also indicated. (B) Amino acid conservation between full-length FoxK and human ILF. Conservation in the FHA and FH domains is indicated. (C) Full-length amino acid sequence of FoxK-L. The FHA and FH domains (both in red) are indicated (FH underlined). Sequence encoded by the alternatively spliced exons 8 and 9 absent in FoxK-S is shown in green. (D) Exon/intron structure of FoxK with the four alternative 5′UTRs (black boxes). The coding region of FoxK extends from exon 2 (ATG) to exon 9 (TGA). The FHA and FH domains are indicated. (E) Structure of FoxK-L transcripts. The hypothetical FoxK-L-RE mRNA lacks part of exon 6. (F) Structure of the FoxK-S transcripts. An alternative splicing that lacks 258 nucleotides between exons 8 and 9 (C and D, green) generates four different FoxK-S mRNAs.