Anti-Nrp2^B treatment reduces tip cell number in dermal lymphatics. (A–D) Control (A and B) and anti-Nrp2^B (C and D)–treated skin showing a reduction in the number of tip cells. The boxed areas in A and C are shown at higher magnifications in B and D, respectively. (E) No change in lymphatic vessel density was noted between control and anti-Nrp2^B–treated samples. (F) A significant reduction in the number of tip cells per high powered field was noted between control and anti-Nrp2^B–treated samples. Error bars indicate SEM. *, P < 0.01. Bars: (A and C) 150 µm; (B and D) 70 µm.