Figure 9. A model of selective sorting and transport of GPI-APs from the ER. After GPI transfer to proteins by the GPI transamidase, the acyl chain linked to inositol in the GPI anchor is eliminated by PGAP1 (1), and a side-chain EtNP on the second mannose of the GPI anchor is removed by PGAP5 (2). These two GPI remodeling reactions in the ER are critical for the sorting of GPI-APs to the ERES. The remodeled GPI-APs are efficiently recognized by the p24 protein family complex that concentrates GPI-APs into the COPII-derived vesicles (3). After transport to the ERGIC or the cis-Golgi, GPI-APs dissociate from the p24 protein family complex because of decreased luminal pH in these compartments (4). The p24 complexes are retrieved from the Golgi to the ER by the COPI vesicles (5).
Figure 9.

A model of selective sorting and transport of GPI-APs from the ER. After GPI transfer to proteins by the GPI transamidase, the acyl chain linked to inositol in the GPI anchor is eliminated by PGAP1 (1), and a side-chain EtNP on the second mannose of the GPI anchor is removed by PGAP5 (2). These two GPI remodeling reactions in the ER are critical for the sorting of GPI-APs to the ERES. The remodeled GPI-APs are efficiently recognized by the p24 protein family complex that concentrates GPI-APs into the COPII-derived vesicles (3). After transport to the ERGIC or the cis-Golgi, GPI-APs dissociate from the p24 protein family complex because of decreased luminal pH in these compartments (4). The p24 complexes are retrieved from the Golgi to the ER by the COPI vesicles (5).

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