Intrachromosomal telomere repeats and proteins associated with telomeric aberrations. (A and B) Ring-like chromosomes with one telomere signal (A) and linear chromosomes with internal telomere signals (B) on the G- (green) and C-strand (red). (C) Telomere-associated proteins TRF1, TRF2, and RAP1 at telomere stretches and bridges. Bars, 10 µm. Yellow arrows point to intrachromosomal telomere signals, and white arrows indicate MPTAs associated with TRF1, TRF2, or RAP1.