Figure 3.
Figure 3. Electron microscopy of telomere attachment sites in WT and Smc1β−/− mice. (A–C) Electron-dense lateral elements (LE) of SCs (A and B) and unsynapsed AEs (C) of pachytene spermatocytes terminate with a conical thickening at the attachment plate. (C) Arrows indicate attachment sites at the NE. (D) For comparison, a WT SC is shown at the same magnification as in C. (E–E″) Three consecutive sections of a series of 12 sections through a pachytene Smc1β−/− spermatocyte showing a full-length SC. The distal telomere (lacking heterochromatin) is attached at the NE (E, arrow), whereas the proximal telomere is not associated with the NE but is free in the nuclear interior. The SC ends in the centromeric heterochromatin mass (CeH). CE, central element. Bars: (A and B) 0.2 µm; (C and D) 0.5 µm; (E–E″) 1 µm.

Electron microscopy of telomere attachment sites in WT and Smc1β−/− mice. (A–C) Electron-dense lateral elements (LE) of SCs (A and B) and unsynapsed AEs (C) of pachytene spermatocytes terminate with a conical thickening at the attachment plate. (C) Arrows indicate attachment sites at the NE. (D) For comparison, a WT SC is shown at the same magnification as in C. (E–E″) Three consecutive sections of a series of 12 sections through a pachytene Smc1β−/− spermatocyte showing a full-length SC. The distal telomere (lacking heterochromatin) is attached at the NE (E, arrow), whereas the proximal telomere is not associated with the NE but is free in the nuclear interior. The SC ends in the centromeric heterochromatin mass (CeH). CE, central element. Bars: (A and B) 0.2 µm; (C and D) 0.5 µm; (E–E″) 1 µm.

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