Figure 4.
The relationship between axon diameter and myelin thickness is normal in dnβ1 mice. (a) Representative electron micrographs of sections of optic nerve, spinal cord, and cerebellum of P28 wild-type and dnβ1 mutant mice. Bar: 1 µm. (b) The linear regression of the g-ratio measurements for each animal (n = 3) is shown for the three CNS areas. Solid and dashed lines represent wild-type and mutant animals, respectively. (c) Scatter plot displays g-ratios of individual myelinated axons (obtained from three animals) as a function of the respective axon size. Closed and open circles represent wild-type and mutant axons, respectively.