Figure 5. Mouse physiology: individual myofiber and whole-muscle analyses. (A and B) Skinned fiber analysis from EDL muscles from 3.5-mo-old male mice (n = 22 wild type; n = 23 ACTCCo/KO) showing the force–Ca2+ relationship (A) and normalized maximum force (B). (C–E) Whole EDL muscle contractile experiments from 10-mo-old male mice (n = 8 for both wild-type and ACTCCo/KO mice) demonstrating the force–frequency relationship (C), normalized maximal force (D), and force loss during fatiguing stimulation and postfatigue recovery (E). Error bars represent ±SEM. *, P < 0.05; **, P < 0.001.
Figure 5.

Mouse physiology: individual myofiber and whole-muscle analyses. (A and B) Skinned fiber analysis from EDL muscles from 3.5-mo-old male mice (n = 22 wild type; n = 23 ACTCCo/KO) showing the force–Ca2+ relationship (A) and normalized maximum force (B). (C–E) Whole EDL muscle contractile experiments from 10-mo-old male mice (n = 8 for both wild-type and ACTCCo/KO mice) demonstrating the force–frequency relationship (C), normalized maximal force (D), and force loss during fatiguing stimulation and postfatigue recovery (E). Error bars represent ±SEM. *, P < 0.05; **, P < 0.001.

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