Plasma membrane domains. (A) Depictions of lattices as multivalent interactions between pentameric Gal-3 and glycoproteins, rafts as a component of STALL by single particle tracking (Suzuki et al., 2007b), and scaffolds as a minimum oligomer of 15 Cav1 molecules. Illustrations are not drawn to scale. (B) Cav1 domains include caveolae, Cav1 scaffolds, and pY14Cav1 scaffold domains in focal adhesions. Cav1 scaffolds may function to restrict signaling of cytokine receptors, such as EGFR, through direct interactions. However, how stable Cav1 domains regulate dynamic raft behavior, both within the plane of the membrane and in the endocytosis of various ligands such as CT-b, remains unclear.