Zmpste24 deficiency promotes stem cell number alterations in mouse skin. (A) Schematic representation of the hair follicle indicating the bulge region where epidermal stem cells are contained. (B and C) Distribution of cytokeratin 15 and α6-integrin in the hair follicle of control and Zmpste24-null animals. (B) Boxed areas are magnified in the bottom panels. (D) Localization and quantification of LRCs in the hair follicle of the indicated mice. **, P < 0.01. Error bars represent SEM. Bars: (B, top; C and D) 100 μm; (B, bottom) 60 μm.