FOCAL POINT (L-R) Debrah Thompson and Roy Parker find that a ribonuclease called Rny1p is mainly localized to the vacuole in yeast cells (left), but stress (right) sends it to the cytoplasm, where it chops up tRNAs and can promote cell suicide. In human cells angiogenin does the tRNA chopping, show Satoshi Yamasaki and Pavel Ivanov, lead authors on Anderson's study.