Infusion of plasmin-digested laminin into lamγ1 KO mice restores neuronal sensitivity to excitotoxins. (A–D) Lamγ1 KO mice were infused with control buffer (A and B) or plasmin-digested laminin (C and D) for 5 d. Control mice were infused with buffer for 5 d and intrahippocampally injected with KA. Silver staining shows that lamγ1 KO mice infused with plasmin-digested laminin (C and D) exhibited much more neuronal death than control buffer–infused mice (A and B), which is comparable with control (Con) mice (E and F). A higher magnification of the boxed areas in A, C, and E are shown in B, D, and F, respectively. (G) Bar graph shows the quantitative result of silver-positive cells in these three groups (n = 7 per group). Ln, laminin-1. Error bars indicate SEM. Bars: (A, C, and E) 0.5 mm; (B, D, and F) 25 μm.