Model of cisplatin-induced cytoskeletal remodeling. The model depicts activation of the ASMase/ceramide pathway by cisplatin as a key step upstream of actin rearrangement. The serine/threonine phosphatase PP2A links ceramide generation to ezrin dephosphorylation and cytosolic relocation. Inactivation of ezrin results in dissociation of actin filaments from the plasma membrane and resorption of cellular filopodia.