DENN proteins form a large family in human cells. A schematic showing the human DENN domain proteins, with the upstream (u-DENN), core DENN, and downstream (d-DENN) regions indicated. Additional domains likely to be of relevance for DENN targeting or regulation are marked and color coded. Sequence alignments of DENNs were done with ClustalX (Chenna et al., 2003) or MUSCLE (Edgar, 2004), and the results were visualized and manipulated with Jalview (Waterhouse et al., 2009). Linear sequence motifs were browsed in the ELM database (Gould et al., 2010). Accession numbers used for this analysis are listed in Table S1.