Figure 4.
Figure 4. Involvement of the ankyrin-binding motif serine residues in Kv-Nav immobilization at the AIS in young neurons. (A) Cell surface distribution of Kv-Nav 4SA (4SA), a phosphodeficient mutant, in DIV 4 hippocampal neurons. Quantification of the cell surface distribution of 4SA is represented on the right and was performed as described in Fig. 3. Data are means ± SEM with n = 144 from four different experiments. Bar, 10 µm. (B and C) Distributions (B) and cumulative frequencies (C) of the instantaneous diffusion coefficients of 4SA (n = 69 trajectories from five independent experiments for 4SA. KS: **, P < 0.01). (D) Histogram of the mean values ± SEM for the immobile population of Kv-Nav and Kv-Nav 4SA. (E) MDC (25–75% IQR) of the mobile population of Kv-Nav and Kv-Nav 4SA.

Involvement of the ankyrin-binding motif serine residues in Kv-Nav immobilization at the AIS in young neurons. (A) Cell surface distribution of Kv-Nav 4SA (4SA), a phosphodeficient mutant, in DIV 4 hippocampal neurons. Quantification of the cell surface distribution of 4SA is represented on the right and was performed as described in Fig. 3. Data are means ± SEM with n = 144 from four different experiments. Bar, 10 µm. (B and C) Distributions (B) and cumulative frequencies (C) of the instantaneous diffusion coefficients of 4SA (n = 69 trajectories from five independent experiments for 4SA. KS: **, P < 0.01). (D) Histogram of the mean values ± SEM for the immobile population of Kv-Nav and Kv-Nav 4SA. (E) MDC (25–75% IQR) of the mobile population of Kv-Nav and Kv-Nav 4SA.

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