FOCAL POINT Cayetano Gonzalez (left) and Jens Januschke show that brain stem cells called neuroblasts rely on the centrosome to store their orientation for division. A neuroblast normally divides so that the daughter cells emerge basally (yellow outline in left panel). But after the researchers depolymerized the neuroblast's microtubules with colcemid (middle panel), a daughter cell (green outline in right panel) could emerge from other locations around the neuroblast.