Fibroblasts from PCNT transgenic mice show an increased number of centrosomes and multipolar spindles. α-tubulin (spindle, green), γ-tubulin (centrosome, red), and DAPI (DNA, blue). MEF, mouse embryonic fibroblast; OE, overexpression. Images provided by A. Krämer (Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center, Heidelberg, Germany).