Figure 3. Effect of extracellular pH on voltage activation of Kv12.2. (A) Normalized GV curves determined in bath solutions of pH 6, 7, and 8 for Kv12.2; experiments were performed as described for Fig. 2 B, except depolarizing steps were limited to 2 s. Data points are mean, error bars show SEM (n = 3–5), curves depict single Boltzmann distribution fits, and the gray line marks −60 mV. (B) V50 versus pH is plotted for Kv12.2 with a three-parameter dose–response fit (pKa 6.9).
Figure 3.

Effect of extracellular pH on voltage activation of Kv12.2. (A) Normalized GV curves determined in bath solutions of pH 6, 7, and 8 for Kv12.2; experiments were performed as described for Fig. 2 B, except depolarizing steps were limited to 2 s. Data points are mean, error bars show SEM (n = 3–5), curves depict single Boltzmann distribution fits, and the gray line marks −60 mV. (B) V50 versus pH is plotted for Kv12.2 with a three-parameter dose–response fit (pKa 6.9).

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