Cartoon of Vps13 bound between membranes and interacting with Mcp1p via its VAB. The chorein-N (orange), extended-chorein (teal), and APT1 (yellow) segments are believed to form a lipid transport channel. The VAB interacts with the Pro-X-Pro motif in the predicted unstructured N-terminus of Mcp1p (indicated). We speculate that the APT1 segment interfaces directly with the integral membrane domain of Mcp1, which harbors scrambling activity, and that there might be a direct handoff of lipids between Vps13p and the scramblase. The ribbons cartoon of the VPS13 lipid transport module was generated using RoseTTAFold (Baek et al., 2021).