Examples of mechanisms regulating cell cycle progression, differentiation, and tumorigenesis mediated by intrinsic caspase-3 cleavage of specific target proteins (Dick et al., 2015; Gabet et al., 2011; Larsen et al., 2010; Man et al., 2017; Naarmann-de Vries et al., 2013; Yosefzon et al., 2018). Caspase-3 mediated proteolytic activity regulates a variety of cellular processes by the cleavage of downstream targets.