Cell adhesion crosstalk with metabolism. FAs associate with mTORC1-positive lysosomes and form a nutrient-sensing hub, which controls spatially restricted GFR signaling, nutrient uptake, and mTORC1 activity. FAs mature into fibrillar adhesions through centripetal movement of α5β1-integrin and a talin-tensin switch. Active mTORC1-positive lysosomes are recruited to fibrillar adhesions, suppress integrin endocytosis, and stabilize fibrillar adhesions. In addition, inhibition of AMPK under nutrient-rich conditions induces tensin transcription, further supporting fibrillar adhesions and integrin activity. Reciprocal control of mTOR and AMPK pathways may play a key role in orchestrating crosstalk between IACs and metabolism.