Figure 4.
Critically ill COVID-19 patients with auto-Abs have a weak nasal IFN-I/III score despite high virus load.(A and B) Comparison of normalized nasal viral load and NP IFN-I/III (IFN) scores in critically ill COVID-19 patients without anti-IFN auto-Abs (A; empty spheres) or with neutralizing auto-Abs (nAb) against IFN-α (B; black triangles). The gray area represents the viral load obtained for 15 out of 17 mildly symptomatic COVID-19 patients (88%) with an IFN-I/III score >6.75 (cutoff value associated with positive viral culture, in red). Dashed lines represent patient with auto-Abs against IFN-α2 only.

Critically ill COVID-19 patients with auto-Abs have a weak nasal IFN-I/III score despite high virus load. (A and B) Comparison of normalized nasal viral load and NP IFN-I/III (IFN) scores in critically ill COVID-19 patients without anti-IFN auto-Abs (A; empty spheres) or with neutralizing auto-Abs (nAb) against IFN-α (B; black triangles). The gray area represents the viral load obtained for 15 out of 17 mildly symptomatic COVID-19 patients (88%) with an IFN-I/III score >6.75 (cutoff value associated with positive viral culture, in red). Dashed lines represent patient with auto-Abs against IFN-α2 only.

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