Figure 2.
Nasal and blood IFN-I/III scores are correlated during SARS-CoV-2 infection. The NP IFN-I/III (IFN) score, defined by a four-ISGs transcriptional signature measured using FilmArray technology, was evaluated. (A) Correlation between the NP IFN-I/III score and the blood IFN-I/III score obtained from the PAXgene whole-blood sample (PX, n = 75 longitudinal samples from 23 patients). The Spearman's correlation coefficient is shown. (B) Correlation between the IFN-I/III score and IFN-α2 levels (fg/ml) in plasma (n = 39 samples with a detectable value from 23 patients), measured by single-molecule array using a commercial kit. The Spearman's correlation coefficient is shown. (C) Kinetic measurements of the NP (green) and blood IFN-I/III scores (red) post COVID-19 diagnosis. n = 75 longitudinal samples from 23 patients. Fit Loess curves represent local polynomial regressions as determined by the Loess method. Confidence interval at 95% is indicated (gray area).

Nasal and blood IFN-I/III scores are correlated during SARS-CoV-2 infection. The NP IFN-I/III (IFN) score, defined by a four-ISGs transcriptional signature measured using FilmArray technology, was evaluated. (A) Correlation between the NP IFN-I/III score and the blood IFN-I/III score obtained from the PAXgene whole-blood sample (PX, n = 75 longitudinal samples from 23 patients). The Spearman's correlation coefficient is shown. (B) Correlation between the IFN-I/III score and IFN-α2 levels (fg/ml) in plasma (n = 39 samples with a detectable value from 23 patients), measured by single-molecule array using a commercial kit. The Spearman's correlation coefficient is shown. (C) Kinetic measurements of the NP (green) and blood IFN-I/III scores (red) post COVID-19 diagnosis. n = 75 longitudinal samples from 23 patients. Fit Loess curves represent local polynomial regressions as determined by the Loess method. Confidence interval at 95% is indicated (gray area).

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