A proposed model for MAPK11/14-mediated phosphorylation of SNX27 inhibits cargo recycling. (A) Under normal conditions, SNX27 recognizes PDZbm-containing cargoes and promotes their recycling from endosomes to the PM. (B) Multiple types of stress activate MAPK11/14, which in turn phosphorylate SNX27 at Ser51. Phosphorylation of SNX27 reduces cargo binding and recycling, leading to enhanced lysosomal degradation.