Overview of the vacuolar biogenesis map. Hierarchical clustering of vacuolar trafficking mutants (left to right) and vacuolar proteins (top to bottom). Proteins in the different mutants are color coded by a gradient from green (low heavy/light ratio) to red (high heavy/light ratio). The legend for the color code is in the bottom left of the figure. Gray fields represent proteins that were not reliably quantified with more than two unique peptides. Clusters for different trafficking pathways are shown: (1) AP-3, (2) endolysosomal/CPY, (3) GGA1/GGA2-dependent accumulation, (4) CVT pathway, (5) sorting defect of V-ATPase subunits in vps45∆ cells, and (6) subunits of protein complexes TORC1 and HOPS.
Figure 2.

Overview of the vacuolar biogenesis map. Hierarchical clustering of vacuolar trafficking mutants (left to right) and vacuolar proteins (top to bottom). Proteins in the different mutants are color coded by a gradient from green (low heavy/light ratio) to red (high heavy/light ratio). The legend for the color code is in the bottom left of the figure. Gray fields represent proteins that were not reliably quantified with more than two unique peptides. Clusters for different trafficking pathways are shown: (1) AP-3, (2) endolysosomal/CPY, (3) GGA1/GGA2-dependent accumulation, (4) CVT pathway, (5) sorting defect of V-ATPase subunits in vps45∆ cells, and (6) subunits of protein complexes TORC1 and HOPS.

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