Graphical overview of clinical TB manifestations and associated transcriptional gene signatures based on Tabone et al. (2021). TB disease is highly heterogenous, but traditional clinical classifications do not reflect this complexity in patients. The Tabone et al. (2021) study (in blue) differentiates blood transcriptional signatures in LTBI individuals who present with incipient disease from those with subclinical disease and from APTB and allows to identify patient that eventually progress to symptomatic APTB and undergo successful TB treatment. White boxes highlight positron emission tomography/computed tomography abnormalities. IGRA, IFN-γ release assay; PET/CT, positron emission tomography/computed tomography.