TBK1 recruitment to STING elevates serum TNF-α and IL-6 levels in DNase II^−/− mice. (A–C) TNF-α levels in the serum of 6-wk-old male (A), 3-mo-old female (B), and 6-mo-old female (C) mice of the indicated genotypes (mean ± SD, n = 4–7 per genotype). (D–F) IL-6 levels in the serum of 6-wk-old male (D), 3-mo-old female (E), and 6-mo-old female (F) mice of the indicated genotypes (mean ± SD, n = 4–7 per genotype). Each dot represents an individual mouse. Statistical analysis was done using a two-tailed, unpaired Student’s test. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Results are representative of two independent experiments.