Figure 4.
AL002c expands metabolically active and proliferating microglia.(A and B) Bar plot of the percentage of cells in cluster 7 (**, P = 6.4 × 10−3; A) and cluster 9 (**, P = 3.4 × 10−3; B) on a per-mouse basis. Data are presented as mean ± SEM. (C) Wilcoxon rank-sum tests comparing cluster 7 to cluster 1 (homeostatic microglia). Genes above the −log(FDR adjusted P values) cutoff of 100 are annotated. (D) Identical to C except comparing cluster 9 to all other clusters. FC, fold-change. (E) Venn diagram showing the number of shared DEGs found with Wilcoxon rank-sum test for cluster 7 and cluster 9. Cluster 7’s DEGs were computed by comparing cluster 7 to cluster 1. Cluster 9’s DEGs were computed by comparing cluster 9 to all other clusters. (F and G) GO term analysis for positive fold-change DEGs in cluster 7 and cluster 9. (H) Mean normalized gene expression grouped by TREM2 variant and antibody treatment in all microglia.

AL002c expands metabolically active and proliferating microglia. (A and B) Bar plot of the percentage of cells in cluster 7 (**, P = 6.4 × 10−3; A) and cluster 9 (**, P = 3.4 × 10−3; B) on a per-mouse basis. Data are presented as mean ± SEM. (C) Wilcoxon rank-sum tests comparing cluster 7 to cluster 1 (homeostatic microglia). Genes above the −log(FDR adjusted P values) cutoff of 100 are annotated. (D) Identical to C except comparing cluster 9 to all other clusters. FC, fold-change. (E) Venn diagram showing the number of shared DEGs found with Wilcoxon rank-sum test for cluster 7 and cluster 9. Cluster 7’s DEGs were computed by comparing cluster 7 to cluster 1. Cluster 9’s DEGs were computed by comparing cluster 9 to all other clusters. (F and G) GO term analysis for positive fold-change DEGs in cluster 7 and cluster 9. (H) Mean normalized gene expression grouped by TREM2 variant and antibody treatment in all microglia.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal