EICE and AICE motifs are enriched at IRF8- and PU.1-binding sites at putative enhancers of Mycl. (A) Schematic representation of putative enhancer regions defined in Fig. 4 A over ChIP-seq tracks for IRF8, IRF4, BATF3, and PU.1 in the indicated cell types. (B) Representative EICE (red) and AICE (blue) DNA binding motifs with PU.1, IRF, and AP-1 binding motifs highlighted. (C–F) Motif analysis of the indicated putative enhancer regions, highlighting predicted AICE and EICE motifs and their respective P value from Find Individual Motif Occurrences analysis. IP, immunoprecipitation.