Characterization of hits identified in both replicates of the nuclear size screens. Example images, distribution of nuclear size (at least 1,000 cells analyzed for each gene, replicate number = 3), distribution analysis data of DRAQ5 staining fluorescence (1,000 cells analyzed for each gene), and FACS of FSC distribution of each hit (at least 2,787 cells analyzed for each gene; other than the four shown in Fig. 5) after knockdown.