Zhx2 inhibits NK cell maturation and function in the tumor microenvironment. (A–D) A murine model of orthotopically HCC was created, and NK cells were harvested for FCM analyses (representative of two independent experiments). (A) Scheme of the experimental design. (B) FCM measurement of HCC TINK cell percentage. (C) Frequency of mature NK cells in the tumor microenvironment. Cells were pregated on CD3−NK1.1+ subsets. (D) CD107a production of TINK cells from Zhx2+/+ and Zhx2Δ/Δ mice. Error bars represent SEM per group in one experiment. Data were analyzed using Student’s t test (two-tailed paired t test). FSC, forward scatter. *, P < 0.05; ***, P < 0.001.
Figure S5.

Zhx2 inhibits NK cell maturation and function in the tumor microenvironment. (A–D) A murine model of orthotopically HCC was created, and NK cells were harvested for FCM analyses (representative of two independent experiments). (A) Scheme of the experimental design. (B) FCM measurement of HCC TINK cell percentage. (C) Frequency of mature NK cells in the tumor microenvironment. Cells were pregated on CD3−NK1.1+ subsets. (D) CD107a production of TINK cells from Zhx2+/+ and Zhx2Δ/Δ mice. Error bars represent SEM per group in one experiment. Data were analyzed using Student’s t test (two-tailed paired t test). FSC, forward scatter. *, P < 0.05; ***, P < 0.001.

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