Susceptibility to αGalCer-induced liver injury in mHVEM−BT/160 mice. Co-housed littermates were injected with 2 µg αGalCer by the retro-orbital route. (A) Representative images of the liver 24 h after injection. Yellow arrowheads indicate necrotic areas. (B) Representative H&E staining of hepatic sections from the indicated mice 24 h after injection. Black dotted lines indicate the necrotic areas. Scale bars, 200 µm. (C and D) Serum ALT activity at 16 and 24 h from the indicated mice. Data shown are mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001 for one-way ANOVA. Data represent pooled results from at least two independent experiments; each experiment is labeled with different colored symbols (n = 4–10 mice per group; co-housed littermates). +/+ are indicated with circles; KI/+ are indicated with triangles; KI/KI are indicated with squares.
Figure 6.

Susceptibility to αGalCer-induced liver injury in mHVEM−BT/160 mice. Co-housed littermates were injected with 2 µg αGalCer by the retro-orbital route. (A) Representative images of the liver 24 h after injection. Yellow arrowheads indicate necrotic areas. (B) Representative H&E staining of hepatic sections from the indicated mice 24 h after injection. Black dotted lines indicate the necrotic areas. Scale bars, 200 µm. (C and D) Serum ALT activity at 16 and 24 h from the indicated mice. Data shown are mean ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001 for one-way ANOVA. Data represent pooled results from at least two independent experiments; each experiment is labeled with different colored symbols (n = 4–10 mice per group; co-housed littermates). +/+ are indicated with circles; KI/+ are indicated with triangles; KI/KI are indicated with squares.

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