Overall structure of hHVEM–hLIGHT–hCD160 ternary complex and critical interaction interfaces of HVEM binding to BTLA, CD160, and LIGHT.(A and B) Structure of the hHVEM–hLIGHT–hCD160 ternary complex indicates hCD160 and hLIGHT can interact simultaneously with hHVEM. The side view (A) and the top/bottom views (B) of the ternary complex are shown. (C) Structure of hHVEM–hBTLA (PDB entry 2AW2). (D) Structure of hHVEM–hCD160 (PDB entry 6NG3). (E) Structure of hHVEM–hLIGHT (PDB entry 4RSU). These structures indicate hBTLA and hCD160 bind to similar surfaces on hHVEM, whereas hLIGHT binds to a different surface on hHVEM. (F–H) Detail binding interfaces between hHVEM and its binding ligands hBTLA, hCD160, and hLIGHT, respectively. The hHVEM CRD1 and CRD2 domains are colored as marine and hot pink, respectively.
Figure 2.

Overall structure of hHVEM–hLIGHT–hCD160 ternary complex and critical interaction interfaces of HVEM binding to BTLA, CD160, and LIGHT. (A and B) Structure of the hHVEM–hLIGHT–hCD160 ternary complex indicates hCD160 and hLIGHT can interact simultaneously with hHVEM. The side view (A) and the top/bottom views (B) of the ternary complex are shown. (C) Structure of hHVEM–hBTLA (PDB entry 2AW2). (D) Structure of hHVEM–hCD160 (PDB entry 6NG3). (E) Structure of hHVEM–hLIGHT (PDB entry 4RSU). These structures indicate hBTLA and hCD160 bind to similar surfaces on hHVEM, whereas hLIGHT binds to a different surface on hHVEM. (F–H) Detail binding interfaces between hHVEM and its binding ligands hBTLA, hCD160, and hLIGHT, respectively. The hHVEM CRD1 and CRD2 domains are colored as marine and hot pink, respectively.

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