Gene expression signatures of CD8⁺ clusters. (A and B) Heatmaps of peripheral-derived CD8 clusters C01-C05 (A) and tumor-derived CD8⁺ clusters C06-C13 (B). Genes displayed are either significantly differentially expressed between CD8⁺ populations or are notable markers of T cell differentiation, function, and exhaustion. Rows represent genes and columns represent individual cells with cluster identities indicated by the color bar on top. (C) Violin plots of key functional and differentiation markers. KLR, killer lectin related gene; ISG, IFN stimulated genes.