Chronic treatment of risperidone or olanzapine did not change plasma levels of insulin, leptin, triglyceride, or NEFA in Mc4r^Sim1-KO mice. (A–D) Plasma levels of insulin (A), leptin (B), triglyceride (C), and NEFA (D) in mice treated with the control (C), risperidone (R), or olanzapine (O) diet; n = 9. One-way ANOVA with Sidak’s post hoc tests. All data were verified in at least two independent experiments. Data are presented as mean ± SEM.