Figure 4.
A subset of MICOS assemblies in wild-type cells are spatially linked to ER–mitochondria MCSs.(A) Left: Airyscan microscopy images of wild-type cells expressing Mic60-3xEGFP (green), mito-dsRed (blue), and HaloTag-HDEL (magenta). Right: Merged time-lapse images of the cell on the left. Arrows indicate a Mic60 assembly that remains in proximity to the ER membrane at the indicated times. White arrows indicate the original Mic60 assembly position and yellow arrows track its movement. See Video 7. (B) As in A for wild-type cells expressing Mic27-3xEGFP (green). See Video 8. (C) As in A for wild-type cells expressing Mic60-3xEGFP (green), mito-DsRed (blue), and Mdm34-HaloTag (magenta). See Video 9 and Video 10. Scale bars = 2 µm.

A subset of MICOS assemblies in wild-type cells are spatially linked to ER–mitochondria MCSs.(A) Left: Airyscan microscopy images of wild-type cells expressing Mic60-3xEGFP (green), mito-dsRed (blue), and HaloTag-HDEL (magenta). Right: Merged time-lapse images of the cell on the left. Arrows indicate a Mic60 assembly that remains in proximity to the ER membrane at the indicated times. White arrows indicate the original Mic60 assembly position and yellow arrows track its movement. See Video 7. (B) As in A for wild-type cells expressing Mic27-3xEGFP (green). See Video 8. (C) As in A for wild-type cells expressing Mic60-3xEGFP (green), mito-DsRed (blue), and Mdm34-HaloTag (magenta). See Video 9 and Video 10. Scale bars = 2 µm.

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