SPRED1 is frequently deleted in human cutaneous melanoma. (A) Diagram representing copy-number losses in the TCGA cohort of human cutaneous melanomas (363 samples). Frequent deletions of CDKN2A on chromosome 9 and PTEN on chromosome 10 are highlighted. SPRED1 was identified by GISTIC analysis in a recurrent focal deletion on chromosome 15. (B) Driver lesions in oncogenes occurring with SPRED1 alterations in human cutaneous melanoma (total, 363 samples). (C) Survival curves of patients with melanoma stratified according to SPRED1 expression levels. High SPRED1, 88 samples (25%) with highest mRNA expression; low SPRED1, 88 samples (25%) with lowest mRNA expression. **, P = 0.0012, log-rank test.