Proposed model for CLASP2-mediated stabilization of KT–MT attachments and promotion of poleward flux. Monomeric CLASP2, targeted to KTs through its C-term (red), integrates multiple independent features, including the recognition of growing MT plus-ends through EB–protein (yellow) interaction and the potential to associate with curved MT protofilaments through TOG2 and TOG3 domains (blue) to promote growth and stabilization of attached MTs required for poleward flux (see main text for details).