A genome-wide RNAi screen identifies the dSTRIPAK complex as a moesin activator. (A) Representation of the dSTRIPAK complex with members controlling moesin phosphorylation identified in screen are highlighted with a blue star. (B and C) The activation score was calculated for each dsRNA on the basis of mean intensity of p-moesin and ranked by increasing score for the primary RNAi screen (B) and secondary confirmation screen (C). Genes known to control moesin phosphorylation are shown with blue stars, and genes of dSTRIPAK are shown with orange stars. Thresholds are marked by dashed lines (see Materials and methods). CTRL, control; Drosophila m., Drosophila melanogaster; Homo s., Homo sapiens; Moe, moesin; PP2Acat, PP2A catalytic subunit.
Figure 1.

A genome-wide RNAi screen identifies the dSTRIPAK complex as a moesin activator. (A) Representation of the dSTRIPAK complex with members controlling moesin phosphorylation identified in screen are highlighted with a blue star. (B and C) The activation score was calculated for each dsRNA on the basis of mean intensity of p-moesin and ranked by increasing score for the primary RNAi screen (B) and secondary confirmation screen (C). Genes known to control moesin phosphorylation are shown with blue stars, and genes of dSTRIPAK are shown with orange stars. Thresholds are marked by dashed lines (see Materials and methods). CTRL, control; Drosophila m., Drosophila melanogaster; Homo s., Homo sapiens; Moe, moesin; PP2Acat, PP2A catalytic subunit.

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